Intraocular axonal swelling produced by partial, immediately retrobulbar ligature of optic nerve.

نویسندگان

  • J D Wirtschafter
  • D E Slagel
  • W J Foxx
  • F J Rizzo
چکیده

This is the first report of an experimental intraorbital ligature producing papilledema characterized by axonal swelling and accumulation of mitochondria in the lamina retinalis of the optic disc of rhesus monkeys subjected to immediately retrobulbar ligature of a portion of the optic nerve. This is an improved technique for investigating the pathogenesis of papilledema and optic neuropathy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Astrocyte processes label for filamentous actin and reorient early within the optic nerve head in a rat glaucoma model.

PURPOSE To determine if astrocyte processes label for actin and to quantify the orientation of astrocytic processes within the optic nerve head (ONH) in a rat glaucoma model. METHODS Chronic intraocular pressure (IOP) elevation was produced by episcleral hypertonic saline injection and tissues were collected after 5 weeks. For comparison, eyes with optic nerve transection were collected at 2 ...

متن کامل

Ischemic model of optic nerve injury.

PURPOSE It is proposed that the anterior optic nerve is specifically susceptible to microcirculatory compromise contributing to the development of glaucomatous optic neuropathy. METHODS Ischemic optic neuropathy was induced by delivering endothelin-1 (ET-1) to the retrobulbar space in one eye of 12 primates for 6 to 12 months. Regional ganglion cell axonal sizes and densities were compared wi...

متن کامل

Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure.

PURPOSE Intraocular pressure (IOP) fluctuations may occur in patients with glaucoma, but how these fluctuations affect axonal populations in the optic nerve and other structures in the eye has been difficult to assess. This study developed a rat model to evaluate the effect of intermittent controlled elevations in IOP on the morphology of the rat optic nerve. METHODS IOP was transiently eleva...

متن کامل

Reversibility of optic nerve damage in primate eyes sub jected to intraocular pressure above systolic blood pressure RONALD

It was shown previously that pressure-induced interruption of axonal transport at the optic nerve head is reversible after 8 hours of raised intraocular pressure (perfusion pressure of 25 to 35 mmHg). Here we report experiments on the nature, location, and reversibility of pressureinduced abnormalities of the optic nerve head, including interruption in axonal transport, in eyes subjected to a m...

متن کامل

Reversibility of optic nerve damage in primate eyes subjected to intraocular pressure above systolic blood pressure.

It was shown previously that pressure-induced interruption of axonal transport at the optic nerve head is reversible after 8 hours of raised intraocular pressure (perfusion pressure of 25 to 35 mmHg). Here we report experiments on the nature, location, and reversibility of pressureinduced abnormalities of the optic nerve head, including interruption in axonal transport, in eyes subjected to a m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Investigative ophthalmology & visual science

دوره 16 6  شماره 

صفحات  -

تاریخ انتشار 1977